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Recent radiation-thermochemical-magnetohydrodynamic simulations resolved formation of quasar accretion disks from cosmological scales down to ~300 gravitational radii $R_g$, arguing they were ‘hyper-magnetized’ (plasma $\beta \ll 1$supported by toroidal magnetic fields) and distinct from traditional $\alpha$-disks. We extend these, refining to $\approx 3R_g$around a BH with multi-channel radiation and thermochemistry, and exploring a factor of 1000 range of accretion rates ( $\dot{m}\sim 0.01-20$). At smaller scales, we see the disks maintain steady accretion, thermalize and self-ionize, and radiation pressure grows in importance, but large deviations from local thermodynamic equilibrium and single-phase equations of state are always present. Trans-Alfvenic and highly-supersonic turbulence persists in all cases, and leads to efficient vertical mixing, so radiation pressure saturates at levels comparable to fluctuating magnetic and turbulent pressures even for $\dot{m}\gg 1$. The disks also become radiatively inefficient in the inner regions at high $\dot{m}$. The midplane magnetic field remains primarily toroidal at large radii, but at super-Eddington $\dot{m}$we see occasional transitions to a poloidal-field dominated state associated with outflows and flares. Large-scale magnetocentrifugal and continuum radiation-pressure-driven outflows are weak at $\dot{m}<1$, but can be strong at $\dot{m}\gtrsim 1$. In all cases there is a scattering photosphere above the disk extending to $\gtrsim 1000R_g$at large $\dot{m}$, and the disk is thick and flared owing to magnetic support (with $H/R$nearly independent of $\dot{m}$), so the outer disk is strongly illuminated by the inner disk and most of the inner disk continuum scatters or is reprocessed at larger scales, giving apparent emission region sizes as large as . 

A practical and convenient method for the efficient and regio- and stereoselective ring-opening of enantiopure monosubstituted epoxides by sodium azide under hydrolytic conditions is reported. The ringopening of enantiopure styryl and pyridyl (S)-epoxides by N3
in hot water takes place preferentially at the internal position with complete inversion of configuration to produce (R)-2-azido ethanols with up to 99% enantio- and regioselectivity, while the (S)-adamantyl oxirane provides mainly the (S)-1-adamantyl- 2-azido ethanol in excellent yield. In general, 1,2-amino ethanols were obtained in high yield and excellent enantiopurity by the reduction of the chiral 1,2-azido ethanols with PPh3 in water/THF, and then converted into the Boc or acetamide derivatives. 

Background The natural history of disease in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remained obscure during the early pandemic. Aim Our objective was to estimate epidemiological parameters of coronavirus disease (COVID-19) and assess the relative infectivity of the incubation period. Methods We estimated the distributions of four epidemiological parameters of SARS-CoV-2 transmission using a large database of COVID-19 cases and potential transmission pairs of cases, and assessed their heterogeneity by demographics, epidemic phase and geographical region. We further calculated the time of peak infectivity and quantified the proportion of secondary infections during the incubation period. Results The median incubation period was 7.2 (95% confidence interval (CI): 6.9‒7.5) days. The median serial and generation intervals were similar, 4.7 (95% CI: 4.2‒5.3) and 4.6 (95% CI: 4.2‒5.1) days, respectively. Paediatric cases < 18 years had a longer incubation period than adult age groups (p = 0.007). The median incubation period increased from 4.4 days before 25 January to 11.5 days after 31 January (p < 0.001), whereas the median serial (generation) interval contracted from 5.9 (4.8) days before 25 January to 3.4 (3.7) days after. The median time from symptom onset to discharge was also shortened from 18.3 before 22 January to 14.1 days after. Peak infectivity occurred 1 day before symptom onset on average, and the incubation period accounted for 70% of transmission. Conclusion The high infectivity during the incubation period led to short generation and serial intervals, necessitating aggressive control measures such as early case finding and quarantine of close contacts.